Alterações endócrinas pós-cirurgia bariátrica: uma revisão integrativa

Autores/as

  • Selma Maria Santos Moura Universidade Federal do Piauí (UFPI), Brasil Autor/a
  • Julio Cesar Viana de Carvalho Junior Universidade Federal do Piauí (UFPI), Brasil Autor/a
  • Mariana Isabela Beserra de Menezes Universidade Federal do Piauí (UFPI), Brasil Autor/a
  • Vanessa da Silva Lima Universidade Federal do Piauí (UFPI), Brasil Autor/a

DOI:

https://doi.org/10.69849/wsf54z18

Palabras clave:

cirurgia bariátrica, pós-operatório, alterações endócrinas

Resumen

A cirurgia bariátrica é uma intervenção eficaz para a obesidade e distúrbios metabólicos relacionados, melhorando significativamente a saúde e aliviando desequilíbrios hormonais. Logo, induz alterações endócrinas complexas que podem levar a disfunções, impactando os eixos somatotrófico, gonadal, tireoidiano, pancreático e adrenal.

Foi realizada uma revisão de estudos avaliados por pares, utilizando as diretrizes PRISMA, com foco em pesquisas com pacientes obesos cujos parâmetros endócrinos foram avaliados em períodos pós-operatórios. Foram pesquisadas as bases PubMed e Scopus, com identificação inicial de 44 artigos, após os critérios de exclusão foram selecionados 22 artigos para a revisão.

De acordo com as pesquisas analisadas de forma integrada, essas mudanças hormonais refletem o impacto sistêmico da cirurgia bariátrica na redução de inflamação crônica, melhora da homeostase glicêmica, restauração de eixos endócrinos comprometidos e mitigação de comorbidades metabólicas. A síntese dos achados reforça que os benefícios do procedimento vão além da perda de peso, envolvendo profundas adaptações endócrinas que contribuem para a melhora clínica global dos pacientes.

Referencias

1-BANDO, Hironori et al. Preoperative Serum Cortisol Level Is Predictive of Weight Loss After Laparoscopic Sleeve Gastrectomy in Men with Severe Obesity but Not Women. Obesity Surgery, [S.l.], v. 33, p. 851-859, 10 jan. 2023. DOI: 10.1007/s11695-022-06415-z.

2- DOWGIAŁŁO-GORNOWICZ, Natalia et al. Predictors of complete remission of type 2 diabetes in patients over 65 years of age - a multicenter study. Obesity Surgery, v. 33, p. 2269-2275, 2023. Disponível em: https://doi.org/10.1007/s11695-023-06705-0. Acesso em: 26 nov. 2025.

3- FERNANDES, B. B. et al. Early Impact of Bariatric Surgery on Brain Functionality. Journal of Metabolic and Bariatric Surgery, v. 14, n. 2, p. 106-123, 2025.

4- HANY, Mohamed et al. Comparative Analysis of Laparoscopic Sleeve Gastrectomy with and Without Prior Endoscopic Intragastric Balloon Insertion: Examining Stomach Volumetry, Histopathologic Changes, Hormonal Levels, and Postoperative Outcomes. Obesity Surgery, [S.l.], v. 35, p. 2039-2052, 13 maio 2025. DOI: 10.1007/s11695-025-07907-4.

5- JAVANI, S. et al. Analysis of semen parameters, and hormonal changes of FSH, LH, testosterone, and libido following bariatric surgery. Original Article [Assumido], 2021.

​6- JUIZ-VALIÑA, P. et al. Altered GH-IGF-1 Axis in Severe Obese Subjects is Reversed after Bariatric Surgery Induced Weight Loss and Related with Low Grade Chronic Inflammation. Journal of Clinical Medicine, v. 9, n. 8, p. 2614, 2020.

7- MAŁCZAK, P. et al. Influence of Bariatric Surgery on Erectile Dysfunction a Systematic Review and Meta Analysis. Obesity Surgery, v. 33, p. 1652–1658, 2023.

8- MEIRA, Inês et al. Diabetes Remission After Bariatric Surgery: A 10-Year Follow-Up Study. Obesity Surgery, v. 35, n. 1, p. 161-169, 2025. Disponível em: https://doi.org/10.1007/s11695-024-07592-9. Acesso em: 26 nov. 2025.

9- MENDES, Cláudia et al. Effect of a 16-Week Exercise Program After Bariatric Surgery on Sarcopenia Parameters Based on FNIH, EWGSOP2, and EASO/ESPEN Criteria: the Results of the EXPOBAR Randomized Trial Program. Obesity Surgery, [S.l.], v. 35, p. 3553-3568, 13 ago. 2025. DOI: 10.1007/s11695-025-08142-7.

10- SUWANNASRISUK, P. et al. Changes in plasma aldosterone level after weight loss by bariatric surgery in morbidly obese patients. BMC Endocrine Disorders, v. 20, n. 45, 2020.

11- TOME, Jawad et al. Breast Cancer Characteristics after Metabolic and Bariatric Surgery: A Matched Comparison to Patients with Severe Obesity. Obesity Surgery, [S.l.], v. 35, p. 2847-2853, 27 maio 2025. DOI: 10.1007/s11695-025-07916-3.

12- ABDULRAZZAQ, S. et al. Is revisional gastric bypass as effective as primary gastric bypass for weight loss and improvement of comorbidities? Obesity Surgery, v. 30, n. 4, p. 1219–1229, 2020. DOI: 10.1007/s11695-019-04280-x.

13- EL ANSARI, W.; ELHAG, W. Weight regain and insufficient weight loss after bariatric surgery: definitions, prevalence, mechanisms, predictors, prevention and management strategies, and knowledge gaps—a scoping review. Obesity Surgery, v. 31, n. 4, p. 1755–1766, 2021. DOI: 10.1007/s11695-020-05160-5.

14- ROMEIJN, M. M. et al. Comparison of linear versus circular-stapled gastroenterostomy in Roux-en-Y gastric bypass: a nationwide population-based cohort study. Obesity Surgery, v. 31, p. 3579–3587, 2021. DOI: 10.1007/s11695-021-05436-4.

15- LAUTENBACH, A. et al. Long-term improvement of chronic low-grade inflammation after bariatric surgery. Obesity Surgery, v. 31, n. 7, p. 2913–2920, 2021. DOI: 10.1007/s11695-021-05315-y.

16- TOLVANEN, L. et al. Patients’ experiences of weight regain after bariatric surgery. Obesity Surgery, v. 32, n. 5, p. 1498–1507, 2022. DOI: 10.1007/s11695-022-05908-1.

17- ABU-KURD, A. et al. Is sleeve gastrectomy as effective in older patients as in younger patients? A comparative analysis of weight loss, related comorbidities, and medication requirements. Obesity Surgery, 2022. DOI: 10.1007/s11695-022-06048-4.

18- Ziegler, A. K., Christensen, M., Jørgensen, H. L., Fenger, M., Myrup, S. F., Dirksen, C., & Madsbad, S. (2025). Effects of bariatric surgery upon the sympathetic nervous system and hypothalamic–pituitary–adrenal axis in obese humans. Scientific Reports. doi:10.1186/s12902-022-01210-4 

19- Šebunova, N., Štšepetova, J., Kullisaar, T., Suija, K., Rätsep, A., Junkin, I., Soeorg, H., Lember, M., Sillakivi, T., & Mändar, R. (2022). Changes in adipokine levels and metabolic profiles following bariatric surgery. BMC Endocrine Disorders, 22(1), 33. doi:10.1186/s12902-022-00942-7 

20- Şahin, Ç., Aydoğdu, Y. F., Büyükkasap, Ç., Dikmen, K., & Dalgıç, A. (2024). Investigation of homocysteine level after bariatric metabolic surgery, effect on vitamin B12 and folate levels. BMC Endocrine Disorders, 24(1), 237. doi:10.1186/s12902-024-01773-4 

21- Tanweer, A. S., Shaheen, M. H., Alshamsi, B. A., Almazrouei, M. A., Almasri, R. M., Shahid Tanveer, A., & Rajeh, J. M. (2025). Endocrine Dysfunction Following Bariatric Surgery: A Systematic Review of Postoperative Changes in Major Endocrine Hormones. Cureus, 17(1), e77756. doi:10.7759/cureus.77756 

22- Suárez-Sánchez, F., Pérez-Ruiz, E., Ramírez-Silva, C. I., Molina-Ayala, M. A., Rivera-Gutiérrez, S., León-Solís, L., García-Morales, L., Rodríguez-González, A., Martínez-Ortiz, C., Meneses-Tapia, L. A., & Cruz-López, M. (2025). Higher magnesium levels are associated with better glycaemic control and diabetes remission post-bariatric surgery. Scientific Reports. doi:10.1038/s41598-025-14537-4

23- Whittemore R, Knafl K. The integrative review: updated methodology. J Adv Nurs. 2005 Dec;52(5):546-53. doi: 10.1111/j.1365-2648.2005.03621.x. PMID: 16268861.

Publicado

2026-04-16

Cómo citar

Moura, S. M. S., Carvalho Junior, J. C. V. de, Menezes, M. I. B. de, & Lima, V. da S. (2026). Alterações endócrinas pós-cirurgia bariátrica: uma revisão integrativa. Revista Ft, 30(157), 01-19. https://doi.org/10.69849/wsf54z18